Water → HCID 11833211, compound

HRID 1861574Notes

Reaction equation

HRID 1861574 reaction equation
[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]=1C(C)(C)C.O.[C:19]([OH:23])(=O)[CH:20]=[O:21].O>ClCCCl.C1(C)C=CC(S(O)(=O)=O)=CC=1>[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH2:5][C:6]1[CH:7]=[C:8]([C:6]([CH3:11])([CH3:7])[CH3:5])[C:9]2[O:12][C:20](=[O:21])[CH:19]([OH:23])[C:10]=2[CH:11]=1

Participants

6

Reactant 3

HCID 962WaterHCID 14474479HCID 14474479, compoundHCID 15620607Glyoxylic acid, monohydrate

Product 1

HCID 11833211HCID 11833211, compoundYield 200%

Reagents, catalysts & solvents 2

HCID 6101p-Toluenesulfonic acidCatalystHCID 111,2-DichloroethaneSolvent

Procedure

23.6 g of 3-(2-tert-butyl-4-hydroxy-phenyl)-propionic acid methyl ester (U.S. Pat. No. 43070-A2), 10.1 g of glyoxylic acid monohydrate and 0.08 g of p-toluenesulfonic acid are boiled in 80 ml of 1,2-dichloroethane for 7 hours using a water separator. The reaction solution is then cooled, washed three times with 50 ml of water each time and freed of solvent using a rotary evaporator. 29.2 g of 3-(7-tert-butyl-3-hydroxy-2-oxo-2,3-dihydro-benzofuran-5-yl)-propionic acid methyl ester are obtained in the form of a yellowish oil. That yellowish oil is placed in 50 ml of toluene with 15 ml of thionyl chloride and 3 drops of DMF and the reaction mixture is then slowly heated to 100° C. at such a rate that the evolution of HCl and SO2 remains vigorous yet controllable. The reaction mixture is then stirred at that temperature for a further hour. Approximately 50 ml of liquid are then distilled off in order to remove the excess thionyl chloride. The residue is diluted with 160 ml of toluene and, at room temperature, 14 ml of triethylamine are added dropwise thereto. The thick, red reaction mixture is then heated under reflux for 30 min. After cooling to room temperature, the triethylamine hydrochloride which has precipitated is filtered off and the filtrate is concentrated to an oily consistency using a rotary evaporator. The isoxindigo is crystallised out by adding 100 ml of acetonitrile, is filtered off, washed with acetonitrile and dried. 7.4 g (27% of the theoretical yield) of 3-[7,7′-di-tert-butyl-2,2′-dioxo-[3,3′]bibenzofuranyliden-5-yl]-5,5′-propionic acid methyl ester (LVIa) are obtained.

Workup

  1. temperatureThe reaction solution is then cooled
  2. washwashed three times with 50 ml of water each time
  3. customa rotary evaporator

Sources & evidence

ORD record
ord-adc7e7ff69f644cfb55b7179fc3c755b
Source dataset
uspto-grants-2003_03
Patent number
US06533825B2

Reaction notes

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