2-Morpholinoethylamine → HCID 69988693, compound

HRID 1861599Notes

Reaction equation

HRID 1861599 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[C@H:11]2[C@H:15]([OH:16])[C@H:14]([OH:17])[C@@H:13]([CH2:18][N:19]3[N:23]=[CH:22][CH:21]=[N:20]3)[O:12]2)=[C:4]([NH:24][CH2:25][CH:26]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[N:3]=1.[NH2:39][CH2:40][CH2:41][N:42]1[CH2:47][CH2:46][O:45][CH2:44][CH2:43]1>CS(C)=O>[CH:14]([OH:17])=[O:45].[C:33]1([CH:26]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:25][NH:24][C:4]2[N:3]=[C:2]([NH:39][CH2:40][CH2:41][N:42]3[CH2:47][CH2:46][O:45][CH2:44][CH2:43]3)[N:10]=[C:9]3[C:5]=2[N:6]=[CH:7][N:8]3[C@H:11]2[C@H:15]([OH:16])[C@H:14]([OH:17])[C@@H:13]([CH2:18][N:19]3[N:23]=[CH:22][CH:21]=[N:20]3)[O:12]2)[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

Participants

4

Reactant 2

HCID 4082852-MorpholinoethylamineHCID 11353104HCID 11353104, compound

Product 1

HCID 69988693HCID 69988693, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Intermediate 3 (0.043 mg), 4-(2-aminoethyl)morpholine (0.053 mg), dimethyl sulphoxide (0.05 ml) ) in a sealed vial (eg Reactivial™) were heated at 90° C. for 16 hours. Purification by Autoprep HPLC afforded after freeze-drying the title compound as a pale yellow solid (0.019 g). LC-MS System A Rt=3.71 min, m/z 627 (MH+).

Workup

  1. customPurification by Autoprep HPLC
  2. customafforded
  3. dry with materialafter freeze-drying the title compound as a pale yellow solid (0.019 g)

Sources & evidence

ORD record
ord-4f4b45c2a077409090398e440cf2ff26
Source dataset
uspto-grants-2003_03
Patent number
US06534486B1

Reaction notes

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