2-Phenylethanol → HCID 18621633, compound

Temperature

0 °C

Potassium hydride (35 wt % in mineral oil, 2.29 g, 20.0 mmol, 2.0 equiv) was stirred in hexanes (10 mL) for 5 min, and then stirring was stopped and the solid allowed to settle. Most of the hexanes layer was removed by pipette, and the residual solvent removed under vacuum. The resulting dry KH powder was suspended in THF (20 mL) and phenethyl alcohol (1.22 g, 10.0 mmol, 1 equiv) was added (causing gas evolution). After stirring at 23° C. for 2.5 h, a thick precipitate formed. The mixture was cooled to 0° C. and a solution of iodomethyltributyltin (prepared according to Seitz, et al., Synth. Commun. (1983), vol. 13, 129) (6.46 g, 15.0 mmol, 1.5 equiv) in THF (15 mL) was added via cannula over 10 min. The mixture was warmed to 23° C. for 3.5 h, and then cooled to −78° C. The reaction was quenched with saturated aqueous NH4Cl solution (25 mL), warmed to 23° C., and extracted with Et2O (200 mL). The organic extracts were dried over MgSO4, filtered, and concentrated. Purification of the residue by flash column chromatography (hexanes) afforded tributyl-phenethyloxymethyl-stannane (3.73 g, 88% yield) as a colorless liquid. Rf=0.63 (4% EtOAc in hexanes). IR (cm−1) 2955, 2924, 2852, 1464, 1082. 1H NMR (CDCl3) δ0.90 (t, J=7.2, 15H), 1.31 (sextet, J=7.4, 6H), 1.50 (quintet, J=7.4, 6H), 2.86 (t, J=7.0, 2H), 3.54 (t, J=7.0, 2H), 3.75 (s, 2H), 7.15-7.33 (m, 5H). 13C NMR (CDCl3) δ9.01, 13.66, 27.28, 29.12, 36.36, 61.94, 76.38, 125.94, 128.17, 128.91, 139.50.

1. customMost of the hexanes layer was removed by pipette
2. customthe residual solvent removed under vacuum
3. customThe resulting dry KH powder
4. stirringAfter stirring at 23° C. for 2.5 h
5. customa thick precipitate formed
6. temperatureThe mixture was warmed to 23° C. for 3.5 h
7. temperaturecooled to −78° C
8. customThe reaction was quenched with saturated aqueous NH4Cl solution (25 mL)
9. temperaturewarmed to 23° C.
10. extractionextracted with Et2O (200 mL)
11. dry with materialThe organic extracts were dried over MgSO4
12. filtrationfiltered
13. concentrationconcentrated
14. customPurification of the residue by flash column chromatography (hexanes)

ORD record

ord-47de12db70e7439c8997a8758a98142d

Source dataset

uspto-grants-2003_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06534530B1