反应详情

To a solution of the compound (43.5 mg) obtained in Example 40 in acetonitrile (5 ml), a solution of hydrogen chloride in 1,4-dioxane (4N, 0.1 ml) and ethyl iodide (50 mg) were added and heated under reflux for 5 h. The reaction mixture was concentrated under reduced pressure and the resulting residue was purified by basic silica gel column chromatography (eluent, methylene chloride methanol=5:1) to give 9.2 mg of the titled compound (yield, 19%).

1. temperatureheated
2. temperatureunder reflux for 5 h
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. customthe resulting residue was purified by basic silica gel column chromatography (eluent, methylene chloride methanol=5:1)