反应详情

To a solution of 8-amino-2-naphthol (8.00 g, 50.3 mmol) in 500 mL of EtOAc and 500 mL of saturated NaHCO3 solution at 0° C. was added chloroacetyl chloride (4.40 mL, 55.2 mmol). After 2 hours, the layers were separated, and the aqueous layer was extracted with EtOAc. The combined organics were washed with brine, dried (Na2SO4), filtered, and concentrated in vacuo. The titled product was obtained as a dark brown solid which was used in the next reaction without further purification.

1. customthe layers were separated
2. extractionthe aqueous layer was extracted with EtOAc
3. washThe combined organics were washed with brine
4. dry with materialdried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated in vacuo