反应详情

To a solution of 4-hydroxy 2,3-dihydro-1H-isoindol-1-one (27) (0.250 gm, 1.67 mmol) in DMF (5 ml) K2CO3 and was added, followed by addition of methyl bromoacetate, and the reaction mixture was stirred at room temperature for 2hr. Then the reaction mixture was then poured on ice and extracted with ethyl acetate (2×15 ml). After the standard workup, the residue was dissolved in methanol (3 ml), and treated with NaOH (5 ml, 1N) at 0° C. and then stirred for and additional hour. After the standard workup, the solid was recrystalized in methanol to give compound 29 (0.140 gm, 60%).

1. additionThen the reaction mixture was then poured on ice
2. extractionextracted with ethyl acetate (2×15 ml)
3. dissolutionAfter the standard workup, the residue was dissolved in methanol (3 ml)
4. additiontreated with NaOH (5 ml, 1N) at 0° C.
5. stirringstirred for and additional hour
6. customAfter the standard workup, the solid was recrystalized in methanol