Hydrochloric Acid → HCID 86588487, compound

HRID 1862528Notes

Reaction equation

HRID 1862528 reaction equation
[CH2:1]([O:8][C:9](=[O:24])[C@@H:10]([NH:20][C:21](=[O:23])[CH3:22])[CH2:11][NH:12]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:25]>C(OCC)(=O)C>[ClH:25].[CH2:1]([O:8][C:9](=[O:24])[C@@H:10]([NH:20][C:21](=[O:23])[CH3:22])[CH2:11][NH2:12])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86588486HCID 86588486, compound

Product 1

HCID 86588487HCID 86588487, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To an ice-cooled solution of N-(t-butoxycarbonyl)-2(S)-acetylamino-β-alanine benzyl ester (3.44 g) in ethyl acetate (35 ml) was added 4N HCl in ethyl acetate (25.5 ml). The mixture was stirred for 2.5 hours at an ambient temperature, then the solvent was decanted. The residue was washed with diethyl ether several times, and dried in vacuo to give 2(S)-acetylamino-β-alanine benzyl ester hydrochloride (2.31 g) as a white powder.

Workup

  1. customthe solvent was decanted
  2. washThe residue was washed with diethyl ether several times
  3. customdried in vacuo

Sources & evidence

ORD record
ord-96058e486db74ff8ae5a354e596b35ea
Source dataset
uspto-grants-2003_03
Patent number
US06538007B1

Reaction notes

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