反应详情

In 33 ml of dimethylformamide, was dissolved 1.1 g of the compound obtained in Example 5. To the resulting solution, was slowly added 325 mg of sodium azide. The obtained reaction solution was stirred at room temperature for 2 hours, and 80 ml of water and 120 ml of ethyl acetate were then added thereto to extract organic substances. The aqueous layer was extracted with 100 ml of ethyl acetate twice. The resulting extract was washed with saturated brine and dried with anhydrous sodium sulfate. The solvent was removed under reduced pressure to afford 925 mg (95%) of the title compound as a light-yellow oil.

1. customThe obtained reaction solution
2. extractionto extract organic substances
3. extractionThe aqueous layer was extracted with 100 ml of ethyl acetate twice
4. extractionThe resulting extract
5. washwas washed with saturated brine
6. dry with materialdried with anhydrous sodium sulfate
7. customThe solvent was removed under reduced pressure