HCID 18620099, compound → HCID 18620128, compound

HRID 1862607Notes

Reaction equation

HRID 1862607 reaction equation
C([O:8][C:9]1[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][O:19][CH2:20][O:21][CH3:22])=[CH:13][C:10]=1[C:11]#[N:12])C1C=CC=CC=1>C(OCC)(=O)C.[C].[Pd]>[OH:8][C:9]1[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][O:19][CH2:20][O:21][CH3:22])=[CH:13][C:10]=1[C:11]#[N:12]

Participants

4

Reactant 1

HCID 18620099HCID 18620099, compound

Product 1

HCID 18620128HCID 18620128, compoundYield 100.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 2-benzyloxy-5-(2-methoxymethoxyethyl)benzonitrile (711 mg) in ethyl acetate (10 ml) was added 10% palladium carbon (100 mg), and the mixture was stirred for 30 minutes at room temperature under a hydrogen atmosphere. After removal of the catalyst by filtration, removal of the solvent under reduced pressure gave 2-hydroxy-5-(2-methoxymethoxyethyl)benzonitrile (496 mg).

Workup

  1. customAfter removal of the catalyst
  2. filtrationby filtration, removal of the solvent under reduced pressure

Sources & evidence

ORD record
ord-a7da5b3e98624f869579df5188a49cd8
Source dataset
uspto-grants-2003_03
Patent number
US06538152B1

Reaction notes

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