Methanesulfonic Acid → HCID 86758892, compound

HRID 1862634Notes

Reaction equation

HRID 1862634 reaction equation
[Cl:1][C:2]1[CH:14]=[C:13]([CH2:15][CH2:16][NH:17][C@@H:18]([CH3:28])[C@H:19]([OH:27])[C:20]2[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=2)[CH:12]=[CH:11][C:3]=1[O:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].[CH3:29][S:30]([OH:33])(=[O:32])=[O:31]>C(O)C>[CH3:29][S:30]([OH:33])(=[O:32])=[O:31].[Cl:1][C:2]1[CH:14]=[C:13]([CH2:15][CH2:16][NH:17][C@@H:18]([CH3:28])[C@H:19]([OH:27])[C:20]2[CH:21]=[CH:22][C:23]([OH:26])=[CH:24][CH:25]=2)[CH:12]=[CH:11][C:3]=1[O:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 10454094HCID 10454094, compound

Product 1

HCID 86758892HCID 86758892, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of ethyl 2-[2-chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]acetate (770 mg) in ethanol (4 ml) was added methanesulfonic acid (79 μl) at room temperature, and the mixture was stirred for 30 minutes. Collection of the resulting precipitates by filtration gave ethyl 2-[2-chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]acetate methanesulfonate (220 mg).

Workup

  1. customCollection of the resulting
  2. customprecipitates by filtration

Sources & evidence

ORD record
ord-2ae8c68d91904453809fb39fa34eebad
Source dataset
uspto-grants-2003_03
Patent number
US06538152B1

Reaction notes

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