Hydrochloric Acid → HCID 178433664, compound

HRID 1862838Notes

Reaction equation

HRID 1862838 reaction equation
[C:1]([NH:3][C:4]([NH:6][CH2:7][C:8]1[N:9]=[CH:10][NH:11][C:12]=1[CH3:13])=[NH:5])#[N:2].[ClH:14].C([OH:18])(C)C>>[ClH:14].[ClH:14].[CH3:13][C:12]1[NH:11][CH:10]=[N:9][C:8]=1[CH2:7][NH:6][C:4]([NH:3][C:1]([NH2:2])=[O:18])=[NH:5]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 178433663HCID 178433663, compound

Product 1

HCID 178433664HCID 178433664, compound

Procedure

1.80 g. (0.0101 mole) N-cyano-N'-[(5-methyl-4-imidazolyl) methyl] guanidine is taken up in 100 ml. isopropanol. 2.5 ml. conc. HCl is added. The reaction mixture is then heated for 20 minutes to reflux and refluxed for 65 minutes to obtain complete hydrolysis. The mixture is then cooled and filtered. The material is then recrystallized from MeOH/CH3CN to obtain 1-[(5-methyl-4-imidazolyl)methylamidino]urea dihydrochloride with a m.p. of 214°-214.5° C.

Workup

  1. temperatureThe reaction mixture is then heated for 20 minutes
  2. temperatureto reflux
  3. temperaturerefluxed for 65 minutes
  4. customto obtain complete
  5. customhydrolysis
  6. temperatureThe mixture is then cooled
  7. filtrationfiltered
  8. customThe material is then recrystallized from MeOH/CH3CN

Sources & evidence

ORD record
ord-7abd9d651eee47f3b0b468ad98b41858
Source dataset
uspto-grants-1979_09
Patent number
US04166860

Reaction notes

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