Hydrochloric Acid → HCID 20393446, compound

HRID 1863120Notes

Reaction equation

HRID 1863120 reaction equation
[CH2:1]([N:3]([CH2:25][CH3:26])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]1[CH:12]=[C:13]([O:23][CH3:24])[C:14]([F:22])=[C:15]2[C:20]=1[N:19]=[CH:18][CH:17]=[C:16]2[CH3:21])[CH3:2].S([O-])([O-])(=O)=O.[Mg+2].[ClH:33]>CCOCC>[ClH:33].[ClH:33].[CH2:25]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]1[CH:12]=[C:13]([O:23][CH3:24])[C:14]([F:22])=[C:15]2[C:20]=1[N:19]=[CH:18][CH:17]=[C:16]2[CH3:21])[CH3:26]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24083Sulfuric acid magnesium salt (1:1)HCID 43230764993-13-1

Product 1

HCID 20393446HCID 20393446, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 28.1 g (0.0779 mole) of 8-(6-diethylaminohexylamino)-5-fluoro-6-methoxy-4-methylquinoline in ether (1.0 l) was dried over anhydrous magnesium sulfate then saturated with anhydrous hydrogen chloride. The gummy solid which separated was collected then recrystallized from ethanol-ether (2:5) (1.4 l); yield 27.3 g (80.8% recovery); mp 263°-269°.

Workup

  1. customThe gummy solid which separated
  2. customwas collected
  3. customthen recrystallized from ethanol-ether (2:5) (1.4 l)

Sources & evidence

ORD record
ord-f84f47a7ae294c9f87e6d0b1354811d6
Source dataset
uspto-grants-1979_09
Patent number
US04167638

Reaction notes

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