反应详情

温度

175 °C

An intimate mixture of 2-(5-amino-2-propoxyphenyl)-8-azapurin-6-one (2 g) and urea (6 g) was heated at 175° C. for one hour. The mixture was then dissolved in water (50 ml) and the solution was acidified by treatment with concentrated hydrochloric acid. The resulting suspension was heated to boiling point and filtered. The solid was dissolved in dilute aqueous ammonia solution (2 N) and this hot solution was acidified by treatment with concentrated hydrochloric acid. The cooled suspension was filtered to give 2-(2-propoxy-5-ureidophenyl)-8-azapurin-6-one (0.7 g), in the form of a microcrystalline solid, m.p. 264°-268° C. (with decomposition).

1. temperatureThe resulting suspension was heated
2. filtrationfiltered
3. dissolutionThe solid was dissolved in dilute aqueous ammonia solution (2 N)
4. filtrationThe cooled suspension was filtered