Hydrochloric Acid → HCID 20392174, compound

HRID 1863152Notes

Reaction equation

HRID 1863152 reaction equation
Cl.[C:2]([CH2:4][NH2:5])#[N:3].[C:6](Cl)(=[O:10])[C:7]([Cl:9])=[O:8].Cl>O1CCOCC1>[C:2]([CH2:4][NH:5][C:6](=[O:10])[C:7]([Cl:9])=[O:8])#[N:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 65578Oxalyl chlorideHCID 11491918Aminoacetonitrile hydrochloride

Product 1

HCID 20392174HCID 20392174, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

20 mM of cyanomethylamine hydrochloride and 25 mM of oxalyl chloride in 100 mM of absolute dioxane are heated at 60-70° while passing through a stream of nitrogen. After one hour a clear solution results and there is no evidence of hydrogen chloride in the nitrogen stream. The solvent is evaporated under vacuum and the residual, light brown oil is taken up in methylene chloride, filtered over charcoal and stored at -30° until it is to be used.

Workup

  1. customAfter one hour a clear solution results
  2. customThe solvent is evaporated under vacuum
  3. filtrationfiltered over charcoal
  4. customstored at -30° until it

Sources & evidence

ORD record
ord-ff5bfcc6e946468899cb58a8ddbca9f2
Source dataset
uspto-grants-1979_09
Patent number
US04168266

Reaction notes

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