反应详情

Prepare a solution of 1.98 g. of glycine methyl ester hydrochloride in dimethylformamide containing 8 ml. of methanol and 1.42 g. of triethylamine. Cool and stir the solution while adding 5.0 g. of t-butoxycarbonylglycine-2,4,5-trichlorophenyl ester in 25 ml. of dimethylformamide. Stir the reaction mixture overnight, filter and evaporate the filtrate to dryness under reduced pressure. Chromatograph the residue on 150 g. of silica gel and collect the desired product which is eluted by an ethyl acetate:chloroform (1:9) mixture. Evaporate the eluate to dryness and crystallize from hexane to obtain the title product (m.p. 132°-135° C.).

1. customPrepare a solution of 1.98 g
2. temperatureCool
3. additionwhile adding 5.0 g
4. stirringStir the reaction mixture overnight
5. filtrationfilter
6. customevaporate the filtrate to dryness under reduced pressure
7. customof silica gel and collect the desired product which
8. washis eluted by an ethyl acetate:chloroform (1:9) mixture
9. customEvaporate the eluate to dryness
10. customcrystallize from hexane