3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

HRID 1863590Notes

Reaction equation

HRID 1863590 reaction equation
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>CC(C)(C)P(C1[CH][CH][CH][CH]1)C(C)(C)C.CC(C)(C)P(C1[CH][CH][CH][CH]1)C(C)(C)C.CN1CCCN2CCCN=C12.CS(=O)(=O)O.CS(C)=O.Nc1ccccc1-c1[c-]cccc1.[Fe].[Pd]>c1ccc(C2CCN(c3cccnc3)CC2)cc1

Participants

6

Reactant 2

HCID 122863-BromopyridineHCID 698734-Phenylpiperidine

Product 1

HCID 1223802233-(4-Phenyl-1-piperidinyl)pyridine

Reagents, catalysts & solvents 3

HCID 1235837-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneReagentHCID 117065439HCID 117065439, compoundCatalystHCID 679Dimethyl SulfoxideSolvent4×

Workup

  1. additionsolution of bipheny (3%) and acetic acid to quench reaction. Acetic acid amount not specified.
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-1a0343c3ed544613893ede8844963b42
Source dataset
Pd-catalyzed Buchwald-Hartwig C-N cross-coupling
Original link
View source

Reaction notes

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