3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

HRID 1863748Notes

Reaction equation

HRID 1863748 reaction equation
Brc1cccnc1.c1ccc(C2CCNCC2)cc1>CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c([PH+](c3ccccc3)c3ccccc3)cccc21.CCN(CC)P1(=NC(C)(C)C)N(C)CCCN1C.CS(C)=O.[CH3-].[NH-]c1ccccc1-c1[c-]cccc1.[Pd]>c1ccc(C2CCN(c3cccnc3)CC2)cc1

Participants

6

Reactant 2

HCID 122863-BromopyridineHCID 698734-Phenylpiperidine

Product 1

HCID 1223802233-(4-Phenyl-1-piperidinyl)pyridine

Reagents, catalysts & solvents 3

HCID 35138512-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amineReagentHCID 132274290HCID 132274290, compoundCatalystHCID 679Dimethyl SulfoxideSolvent4×

Workup

  1. additionsolution of bipheny (3%) and acetic acid to quench reaction. Acetic acid amount not specified.
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-509fe6eb31144973bd049c2fbc287918
Source dataset
Pd-catalyzed Buchwald-Hartwig C-N cross-coupling
Original link
View source

Reaction notes

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