Hydrochloric Acid → HCID 87483712, compound

HRID 1863952Notes

Reaction equation

HRID 1863952 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH2:27][C:28]1[CH:33]=[C:32]([F:34])[C:31]([F:35])=[CH:30][C:29]=1[F:36])[CH2:9][C:10]1[N:14]2[CH2:15][CH2:16][C:17]3[C:18](=[N:19][C:20]([C:23]([F:26])([F:25])[F:24])=[N:21][CH:22]=3)[C:13]2=[N:12][N:11]=1)(C)(C)C.[ClH:38]>O1CCOCC1>[ClH:38].[F:36][C:29]1[CH:30]=[C:31]([F:35])[C:32]([F:34])=[CH:33][C:28]=1[CH2:27][C@@H:8]([NH2:7])[CH2:9][C:10]1[N:14]2[CH2:15][CH2:16][C:17]3[C:18](=[N:19][C:20]([C:23]([F:24])([F:26])[F:25])=[N:21][CH:22]=3)[C:13]2=[N:12][N:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90695481HCID 90695481, compound

Product 1

HCID 87483712HCID 87483712, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 47 mg (0.89 mmol) of tert-butyl{(1R)-1-(2,4,5-trifluorobenzyl)-2-[9-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4′,3′:1,2]pyrido[3,4-d]pyrimidin-3-yl]ethyl}carbamate was added 1.8 mL of 4M HCl in anhydrous dioxane. The mixture was stirred at room temperature for 30 minutes and then concentrated. The residue was washed with diethyl ether and dried to give the title compound as a white solid. LC-MS 429 (M+1).

Workup

  1. concentrationconcentrated
  2. washThe residue was washed with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-e1d287dcad2146fb94e045a132434b34
Source dataset
uspto-grants-2009_12
Patent number
US07625888B2

Reaction notes

Loading…