HCID 68522763, compound → HCID 57973809, compound

HRID 1863965Notes

Reaction equation

HRID 1863965 reaction equation
[N:1]1[N:2]=[C:3]([CH2:13][C@H:14]([NH:25]C(=O)C)[CH2:15][C:16]2[CH:21]=[C:20]([F:22])[C:19]([F:23])=[CH:18][C:17]=2[F:24])[N:4]2[CH:9]=[CH:8][C:7]3=[N:10][CH:11]=[N:12][N:6]3[C:5]=12>Cl>[N:1]1[N:2]=[C:3]([CH2:13][C@H:14]([NH2:25])[CH2:15][C:16]2[CH:21]=[C:20]([F:22])[C:19]([F:23])=[CH:18][C:17]=2[F:24])[N:4]2[CH:9]=[CH:8][C:7]3=[N:10][CH:11]=[N:12][N:6]3[C:5]=12

Participants

3

Reactant 1

HCID 68522763HCID 68522763, compound

Product 1

HCID 57973809HCID 57973809, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 26.1 mg (0.067 mmol) of N-[(1R)-2-bis[1,2,4]triazolo[1,5-c:4′,3′-a]pyrimidin-3-yl-1-(2,4,5-trifluorobenzyl)ethyl]acetamide in 3 mL of 6N hydrochloric acid was stirred at reflux under nitrogen for 12 h. The solution was evaporated to dryness, and the residue was purified by preparative thin-layer chromatography on silica gel (90:10:1 dichloromethane:methanol:concentrated ammonium hydroxide) to give the title compound as a white solid. LC-MS 348 (M+1).

Workup

  1. temperatureat reflux under nitrogen for 12 h
  2. customThe solution was evaporated to dryness
  3. customthe residue was purified by preparative thin-layer chromatography on silica gel (90:10:1 dichloromethane:methanol:concentrated ammonium hydroxide)

Sources & evidence

ORD record
ord-ca699f3a32544fcd9e601236ea197634
Source dataset
uspto-grants-2009_12
Patent number
US07625888B2

Reaction notes

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