Hydrochloric Acid → 3-{[6-(4-fluorophenyl)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl]carbonyl}benzylamine hydrochloride

HRID 1863995Notes

Reaction equation

HRID 1863995 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]3[CH2:14][N:15]([C:19]([C:21]4[CH:22]=[C:23]([CH:33]=[CH:34][CH:35]=4)[CH2:24][NH:25]C(=O)OC(C)(C)C)=[O:20])[CH2:16][CH2:17][O:18][C:12]=3[N:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[ClH:36]>C(OCC)(=O)C>[ClH:36].[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]3[CH2:14][N:15]([C:19]([C:21]4[CH:22]=[C:23]([CH:33]=[CH:34][CH:35]=4)[CH2:24][NH2:25])=[O:20])[CH2:16][CH2:17][O:18][C:12]=3[N:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67180248tert-butyl 3-{[6-(4-fluorophenyl)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl]carbonyl}benzylcarbamate

Product 1

HCID 671796703-{[6-(4-fluorophenyl)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl]carbonyl}benzylamine hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To tert-butyl 3-{[6-(4-fluorophenyl)-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl]carbonyl}benzylcarbamate (0.32 g) obtained in Example 72C was added a 4N solution (10 ml) of hydrochloric acid in ethyl acetate, and the mixture was stirred at room temperature for 30 min. The reaction mixture was concentrated and the residue was dissolved in a small amount of isopropanol. Ethyl acetate was added and the resulting crystals were collected by filtration to give the title compound (0.25 g) as colorless crystals.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in a small amount of isopropanol
  3. additionEthyl acetate was added
  4. filtrationthe resulting crystals were collected by filtration

Sources & evidence

ORD record
ord-bcf9aef530d844edba30dcf9bb90bf8a
Source dataset
uspto-grants-2009_12
Patent number
US07625887B2

Reaction notes

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