Methylamine → HCID 86587285, compound

HRID 1864090Notes

Reaction equation

HRID 1864090 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[CH:6]=O.[CH3:17][NH2:18]>C1COCC1>[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[CH:6]=[N:18][CH3:17]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 1362473,5-Bis(trifluoromethyl)benzaldehyde

Product 1

HCID 86587285HCID 86587285, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 3,5-bis(trifluoromethyl)-benzaldehyde (412 μL) in dry THF (5 mL) was added dropwise to a solution of methylamine (2M in MeOH-3.12 mL) in dry THF (5 mL) at 23° C. under a nitrogen atmosphere. The reaction mixture was stirred overnight, then the solvent was evaporated in vacuo to give the title compound (385 mg) as a colourless oil.

Workup

  1. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-e03639e5b80f490d808b7cf20d14e43c
Source dataset
uspto-grants-2009_12
Patent number
US07625904B2

Reaction notes

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