Dimethylformamide → {4-[1-(2-Fluoro-4-methanesulfonyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy]-piperidin-1-yl}-(4-trifluoromethoxy-phenyl)-methanone

HRID 1864141Notes

Reaction equation

HRID 1864141 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:12]1[C:16]2=[N:17][CH:18]=[N:19][C:20]([O:21][CH:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)=[C:15]2[CH:14]=[N:13]1.C(N(CC)CC)C.[F:35][C:36]([F:48])([F:47])[O:37][C:38]1[CH:46]=[CH:45][CH:44]=[CH:43][C:39]=1C(Cl)=O.CN([CH:52]=[O:53])C>>[F:1][C:2]1[CH:7]=[C:6]([S:8]([CH3:11])(=[O:9])=[O:10])[CH:5]=[CH:4][C:3]=1[N:12]1[C:16]2=[N:17][CH:18]=[N:19][C:20]([O:21][CH:22]3[CH2:23][CH2:24][N:25]([C:52]([C:44]4[CH:43]=[CH:39][C:38]([O:37][C:36]([F:35])([F:47])[F:48])=[CH:46][CH:45]=4)=[O:53])[CH2:26][CH2:27]3)=[C:15]2[CH:14]=[N:13]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 27772412-(Trifluoromethoxy)benzoyl ChlorideHCID 218975531-(2-fluoro-4-methanesulfonyl-phenyl)-4-(piperidin-4-yloxy)-1H-pyrazolo[3,4-d]pyrimidine

Product 1

HCID 21897805{4-[1-(2-Fluoro-4-methanesulfonyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy]-piperidin-1-yl}-(4-trifluoromethoxy-phenyl)-methanone

Conditions

Temperature
0 °C

Procedure

In a 50 mL round-bottomed flask was placed 1-(2-fluoro-4-methanesulfonyl-phenyl)-4-(piperidin-4-yloxy)-1H-pyrazolo[3,4-d]pyrimidine (300 mg, 0.7 mmol) and triethylamine (584 μl). DMF (6 mL) was added to completely dissolve the solid material. The reaction flask was immersed in an ice-bath. Trifluoromethoxybenzoyl chloride (180 mg, 0.8 mmol) was added to the solution and the mixture was stirred 2 h under N2 at 0° C. After all of the starting amine was completely converted as indicated by LCMS, the reaction was stopped by quenching with water. The reaction mixture was then concentrated under vacuum and purified by preparative HPLC. 1H NMR (CDCl3, 400MHz) δ 1.98 (m, 1H), 2.12 (m, 2H), 2.27 (m, 1H), 3.13 (s, 3H), 3.51 (m, 1H), 3.79 (m, 2H), 4.21 (m, 1H), 5.76 (m, 1H), 7.31 (d, 2H), 7.52 (d, 2H), 7.95 (m, 3H), 8.36 (s, 1H), 8.65 (s, 1H). Exact mass calculated for C25H21F4N5O5S 579.12, found 580.2 (MH+).

Workup

  1. customIn a 50 mL round-bottomed flask was placed
  2. dissolutionto completely dissolve the solid material
  3. customThe reaction flask was immersed in an ice-bath
  4. customby quenching with water
  5. concentrationThe reaction mixture was then concentrated under vacuum
  6. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-84ebb6afb70440239b6048b483147b76
Source dataset
uspto-grants-2009_12
Patent number
US07625906B2

Reaction notes

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