Sodium Iodide → HCID 25027252, compound

HRID 1864458Notes

Reaction equation

HRID 1864458 reaction equation
[C:1]1([S:7]([N@:10]2[CH2:12][CH:11]2[C:13]([N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[C:25]([CH3:27])[CH:24]=[CH:23][C:22]=3[CH3:28])[CH2:17][CH2:16]2)=[O:14])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[I-:29].[Na+].Br[CH2:32][CH2:33][CH2:34][N:35]=[C:36]=[O:37]>>[C:1]1([S:7]([N:10]2[CH2:12][C@@H:11]([C:13]([N:15]3[CH2:16][CH2:17][N:18]([C:21]4[CH:26]=[C:25]([CH3:27])[CH:24]=[CH:23][C:22]=4[CH3:28])[CH2:19][CH2:20]3)=[O:14])[N:35]([CH2:34][CH2:33][CH2:32][I:29])[C:36]2=[O:37])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 5238Sodium IodideHCID 5445441-Bromo-3-isocyanatopropaneHCID 178425107HCID 178425107, compound

Product 1

HCID 25027252HCID 25027252, compound

Procedure

In analogy to example 2, ((S)-1-benzenesulfonyl-aziridin-2-yl)-[4-(2,5-dimethyl-phenyl)-piperazin-1-yl]-methanone (example 21, step 3) was reacted with sodium iodide and 3-bromopropylisocyanate to give the title compound as a light yellow foam. MS: 610.6 ([M+H]+)

Sources & evidence

ORD record
ord-c9d41d261926416987c53a9877ea0e0a
Source dataset
uspto-grants-2009_12
Patent number
US07625902B2

Reaction notes

Loading…