Sodium Iodide → HCID 67141748, compound

HRID 1864468Notes

Reaction equation

[CH3:1][O:2][C:3]([CH:5]1[CH2:7][N:6]1[S:8]([CH:11]([CH3:13])[CH3:12])(=[O:10])=[O:9])=[O:4].[I-].[Na+].[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[N:23]=[C:24]=[O:25]>>[CH3:1][O:2][C:3]([CH:5]1[CH2:7][N:6]([S:8]([CH:11]([CH3:12])[CH3:13])(=[O:9])=[O:10])[C:24](=[O:25])[N:23]1[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[Cl:16])=[O:4]

Participants

Reactant 3

HCID 5238Sodium Iodide

HCID 76833Chlorophenyl isocyanate

HCID 86623486HCID 86623486, compound

Product 1

HCID 67141748HCID 67141748, compound

Procedure

In analogy to example 1, the crude 1-(propane-2-sulfonyl)-aziridine-2-carboxylic acid methyl ester from example 82, step 1 was reacted with sodium iodide and 2-chlorophenyl isocyanate to give (RS)-3-(2-chloro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid methyl ester as a light yellow oil. MS: 361.1 ([M+H]+)

Sources & evidence

ORD record: ord-6dfb11c9588544ef8cb2285298b89bce
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07625902B2

Reaction notes

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