Sodium Iodide → HCID 25027717, compound

HRID 1864473Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C@@H:17]2[CH2:21][N:20]([S:22]([C:25]3[C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH:28]=[CH:27][CH:26]=3)(=[O:24])=[O:23])[C:19](=[O:35])[NH:18]2)=[O:16])[CH2:11][CH2:10]1.[CH2:36](I)[CH2:37][CH3:38].[I-].[Na+]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C@@H:17]2[CH2:21][N:20]([S:22]([C:25]3[C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH:28]=[CH:27][CH:26]=3)(=[O:24])=[O:23])[C:19](=[O:35])[N:18]2[CH2:36][CH2:37][CH3:38])=[O:16])[CH2:11][CH2:10]1

Participants

Reactant 3

HCID 5238Sodium Iodide

HCID 336431-Iodopropane

HCID 67141129HCID 67141129, compound

Product 1

HCID 25027717HCID 25027717, compound

Procedure

In analogy to example 66, step 4, (S)-4-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-1-(naphthalene-1-sulfonyl)-imidazolidin-2-one and propyl iodide were reacted in the presence of sodium iodide in a pressure tube to yield (S)-4-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-1-(naphthalene-1-sulfonyl)-3-propyl-imidazolidin-2-one as a white solid. MS: 535.0 ([M+H])

Sources & evidence

ORD record: ord-da81366189054d9b8f3f87fee9b0ddb0
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07625902B2

Reaction notes

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