Trifluoroacetic acid → HCID 45096892, compound

HRID 1864484Notes

Reaction equation

HRID 1864484 reaction equation
COC(=O)[CH2:4][N:5]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:6][CH:7]([NH:9][C:10](OC(C)(C)C)=[O:11])[CH3:8].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:17]([N:5]1[CH2:6][C@H:7]([CH3:8])[NH:9][C:10](=[O:11])[CH2:4]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 60208241HCID 60208241, compound

Product 1

HCID 45096892HCID 45096892, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Ester (2) was stirred in a 50:50 solution of TFA:CH2Cl2 for 1 hour. The solvent was then removed, and the residue was redissolved in methylene chloride and washed with a saturated solution of Na2CO3. The organic layer was then separated and dried over MgSO4 giving desired piperazine compound (3) as a white solid (87%).

Workup

  1. customThe solvent was then removed
  2. dissolutionthe residue was redissolved in methylene chloride
  3. washwashed with a saturated solution of Na2CO3
  4. customThe organic layer was then separated
  5. dry with materialdried over MgSO4 giving desired piperazine compound (3) as a white solid (87%)

Sources & evidence

ORD record
ord-cc1a1e3b2fea47c2a517300880cf2161
Source dataset
uspto-grants-2009_12
Patent number
US07625909B2

Reaction notes

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