反应详情

Add potassium carbonate (5.2 g, 37.9 mmol) to 3-bromo-4-hydroxy-benzonitrile (5.0 g, 25.2 mmol) in acetone with stirring at room temperature. After 15 minutes, add iodoethane (2.4 mL, 130.3 mmol) and continue stirring at room temperature. After 18 hours, pour the reaction mixture into water and extract with EtOAc. Combine the organic extracts, wash with water and brine, dry over anhydrous magnesium sulfate, filter, and concentrate under reduced pressure. Purify the residue by flash chromatography eluting with ethyl acetate:hexanes to provide the title compound.

1. stirringcontinue stirring at room temperature
2. waitAfter 18 hours
3. extractionextract with EtOAc
4. washwash with water and brine
5. dry with materialdry over anhydrous magnesium sulfate
6. filtrationfilter
7. concentrationconcentrate under reduced pressure
8. customPurify the residue by flash chromatography
9. washeluting with ethyl acetate