Ethyl cyanoacetate → Ethyl 4-cyano-3-[4-(3-cyano(2-thienyl))phenyl]pyrrole-2-carboxylate
Reaction equation
[C:1]([C:3](S(C1C=CC(C)=CC=1)(=O)=O)=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:12][CH:13]=[CH:14][C:15]=2[C:16]#[N:17])=[CH:7][CH:6]=1)#[N:2].C([CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])#N.[N:36]12CCCN=C1CCCC[CH2:37]2>>[C:37]([C:3]1[C:4]([C:5]2[CH:6]=[CH:7][C:8]([C:11]3[S:12][CH:13]=[CH:14][C:15]=3[C:16]#[N:17])=[CH:9][CH:10]=2)=[C:30]([C:31]([O:33][CH2:34][CH3:35])=[O:32])[NH:2][CH:1]=1)#[N:36]Participants
4
Procedure
In a manner analogous to the procedure set forth in example A-239, the title compound is prepared from 2-(4-{2-cyano-2-[(4-methylphenyl)sulfonyl]vinyl}phenyl)thiophene-3-carbonitrile, prepared directly above, ethyl cyanoacetate and 1,8-diazabicyclo[5.4.0]undec-7-ene.
Sources & evidence
- ORD record
- ord-ff6a01c2b0fb4eb38566a4203d96f2f8
- Source dataset
- uspto-grants-2009_12
- Patent number
- US07625932B2
Reaction notes
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