Dimethyl Sulfate → HCID 11392341, compound

HRID 1865181Notes

Reaction equation

HRID 1865181 reaction equation
[CH3:1][NH:2][C:3]([C:5]1[NH:13][C:12]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[C:6]=1[S:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:4].[CH3:21]OS(OC)(=O)=O>CN(C=O)C>[CH3:1][NH:2][C:3]([C:5]1[N:13]([CH3:21])[C:12]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[C:6]=1[S:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:4]

Participants

4

Reactant 2

HCID 6497Dimethyl SulfateHCID 11196840HCID 11196840, compound

Product 1

HCID 11392341HCID 11392341, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Treat 3-phenylsulfanyl-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid methylamide Ia-33 (1.0 equiv) in DMF with dimethylsulfate (1.5 equiv) as described in General Synthetic Procedure V to provide Ia-29 as an ivory colored solid, MS Obs 298.09 (M+1).

Workup

  1. customto provide Ia-29 as an ivory colored solid, MS Obs 298.09 (M+1)

Sources & evidence

ORD record
ord-1caa879758aa42a4b38751c5a2aee8fa
Source dataset
uspto-grants-2009_12
Patent number
US07626027B2

Reaction notes

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