Dimethylformamide → Tert-butyl 4-(2-oxo-1,2,4,5-tetrahydrobenzo[d][1,3]diazepin-3-yl)piperidine-1-carboxylate

HRID 186519Notes

Reaction equation

HRID 186519 reaction equation
[C:1](=[O:2])([c:3]1[nH:4][cH:5][cH:6][n:7]1)[c:8]1[nH:9][cH:10][cH:11][n:12]1.[CH3:36][N:37]([CH3:38])[CH:39]=[O:40].[CH3:41][CH2:42][O:43][C:44](=[O:45])[CH3:46].[NH2:13][c:14]1[c:15]([CH2:20][CH2:21][NH:22][CH:23]2[CH2:24][CH2:25][N:26]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:27][CH2:28]2)[cH:16][cH:17][cH:18][cH:19]1>>[C:1]1(=[O:2])[NH:13][c:14]2[c:15]([cH:16][cH:17][cH:18][cH:19]2)[CH2:20][CH2:21][N:22]1[CH:23]1[CH2:24][CH2:25][N:26]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:27][CH2:28]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 18444264Tert-butyl 4-{[2-(2-aminophenyl)ethyl]amino}piperidine-1-carboxylate

Product 1

HCID 58823744Tert-butyl 4-(2-oxo-1,2,4,5-tetrahydrobenzo[d][1,3]diazepin-3-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-8871aa1175c648cc8a84d24c6c296b43
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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