Hydrochloric Acid → HCID 67377193, compound

HRID 1865291Notes

Reaction equation

HRID 1865291 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:24])=[C:11]([N:15]4[CH2:20][CH2:19][CH:18]([NH2:21])[C:17]([CH3:23])([CH3:22])[CH2:16]4)[C:12]=3[CH3:14])[C:7](=[O:25])[C:6]([C:26]([OH:28])=[O:27])=[CH:5]2)[CH2:3][CH2:2]1.[ClH:29].CCOCC>C(O)C>[ClH:29].[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:24])=[C:11]([N:15]4[CH2:20][CH2:19][CH:18]([NH2:21])[C:17]([CH3:22])([CH3:23])[CH2:16]4)[C:12]=3[CH3:14])[C:7](=[O:25])[C:6]([C:26]([OH:28])=[O:27])=[CH:5]2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 10221813HCID 10221813, compound

Product 1

HCID 67377193HCID 67377193, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product obtained in example 70 (1 gm; 2.58 mmol) was suspended in 10 ml ethanol and ethanolic hydrochloric acid (2.6 ml) was added at a temperature between 20-30° C. under stirring. To this solution, 20 ml ether was added after 30 minutes and the solid separated was filtered and dried under vacuum. Yield—0.86 gm (83%). m. p. (by DSC) 300° C., C21H26FN3O3.HCl, m/z 388 (M+1), [α]D25 value=+2750 (c=0.5, methanol).

Workup

  1. customthe solid separated
  2. filtrationwas filtered
  3. customdried under vacuum
  4. custom(by DSC) 300° C., C21H26FN3O3.HCl, m/z 388 (M+1), [α]D25 value=+2750 (c=0.5, methanol)

Sources & evidence

ORD record
ord-326697ef677443b09b8afe0c117788a8
Source dataset
uspto-grants-2009_12
Patent number
US07626032B2

Reaction notes

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