Phosphorus oxychloride → 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine

HRID 1865781Notes

Reaction equation

O[C:2]1[N:7]=[CH:6][N:5]=[C:4]2[NH:8][N:9]=[CH:10][C:3]=12.O=P(Cl)(Cl)[Cl:13]>>[Cl:13][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[NH:8][N:9]=[CH:10][C:3]=12

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 178518059HCID 178518059, compound

Product 1

HCID 2210954-Chloro-1H-pyrazolo[3,4-d]pyrimidine

Procedure

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine was synthesized from 4-hydroxypyrazolo[3,4-d]pyrimidine and POCl3 as described by R. Robins in J. Am. Chem. Soc., 1957, V. 79, N20, P. 6407-6415.

Sources & evidence

ORD record: ord-6aa3df71c00a4d14bcd8dcd8e31989f4
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07629320B2

Reaction notes

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