3-Amino-1-propanol → HCID 11407192, compound

Temperature

-5 °C

A suspension of 5-[bis(2-chloroethyl)amino]-2,4-dinitrobenzoic acid [Palmer et al., J. Med. Chem., 1994, 37, 2175] (1) (2.50 g, 7.1 mmol) in SOCl2 (20 mL) containing DMF (2 drops) was heated under reflux for1 h, then concentrated to dryness under reduced pressure and re-evaporated with benzene. The resulting crude benzoyl chloride was dissolved in Me2CO (50 mL) and the cooled (−5° C.) solution was treated with a cold solution of 3-amino-1-propanol (1.09 g, 14.5 mmol) in water (25 mL). The reaction mixture was shaken at room temperature for 5 min, then diluted with water (25 mL), concentrated to half volume, and extracted with CH2Cl2 (2×). The organic extract was washed with 0.1 N HCl and water then worked up to give a solid which was chromatographed on silica gel, eluting with EtOAc to give IIa-3 (2.37 g, 82%): mp (EtOAc/i-Pr2O) 90-91° C.; 1H [(CD3)2SO] δ8.63 (t, J=5.6 Hz, 1 H, CONH), 8.53 (s, 1 H, H-3), 7.42 (s, 1 H, H-6), 4.46 (t, J=5.1 Hz, 1 H, OH), 3.82 (t, J=5.9 Hz, 4 H, N(CH2CH2Cl)2), 3.68 (t, J=5.9 Hz, 4 H, N(CH2CH2Cl)2), 3.49 (q, J=6.0 Hz, 2 H, CH2OH), 3.29 (q, partially obscured, J=5.9 Hz, 2 H, CONHCH2), 1.68 (pent, J=6.7 Hz, 2 H, CH2CH2CH2). Anal. (C14H18Cl2N4O6) C, H, N, Cl.

1. temperaturewas heated
2. temperatureunder reflux for1 h
3. concentrationconcentrated to dryness under reduced pressure
4. customre-evaporated with benzene
5. dissolutionThe resulting crude benzoyl chloride was dissolved in Me2CO (50 mL)
6. concentrationconcentrated to half volume
7. extractionextracted with CH2Cl2 (2×)
8. extractionThe organic extract
9. washwas washed with 0.1 N HCl and water
10. customto give a solid which
11. customwas chromatographed on silica gel
12. washeluting with EtOAc
13. customto give IIa-3 (2.37 g, 82%)

ORD record

ord-f5e534e2e15f403cb72b9e8532f54437

Source dataset

uspto-grants-2009_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07629332B2