反应详情

To a solution of 1.87 g 5-bromo-3-(4-fluoro-phenyl)-pyrazin-2-ylamine in 35 ml methanol was added 15 ml ethyl acetate, 0.260 g [1,1′-bis(diphenylphosphino)ferrocen]palladium(II)chloride 1:1 complex with dichloromethane and 1.95 ml triethylamine and the mixture was stirred at 110° C. under 70 bar carbon monoxide for 18 h. The reaction mixture was evaporated and the residue was purified by chromatography on silica gel with heptane:ethyl acetate=1:1 to yield 1.26 g of the title compound as white crystals. MS (ISP) (M+H+)=248.3.

1. customThe reaction mixture was evaporated
2. customthe residue was purified by chromatography on silica gel with heptane