反应详情

A solution of 4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine (219 mg, 1 mmol) in DMF (2 mL) at 0° C. was treated with NaH (40 mg, 60%, 1 mmol), stirred for 20 min, treated with 2-fluorobenzyl bromide (120 μL, 1 mmol), stirred at room temperature for 1 h, quenched with water, extracted with EtOAc, dried (MgSO4), concentrated in vacuo and purified by chromatography (EtOAc:Heptane, 1:4) to give the title compound (250 mg, 76%) as a cream solid.

1. stirringstirred at room temperature for 1 h
2. customquenched with water
3. extractionextracted with EtOAc
4. dry with materialdried (MgSO4)
5. concentrationconcentrated in vacuo
6. custompurified by chromatography (EtOAc:Heptane, 1:4)