Azobisisobutyronitrile → HCID 67211616, compound

HRID 1866591Notes

Reaction equation

[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[SH:11].[CH:12]12[CH2:18][CH:15]([CH:16]=[CH:17]1)[CH2:14][CH:13]2[C:19]([OH:21])=[O:20].N(C(C)(C)C#N)=NC(C)(C)C#N>O1CCCC1>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11][CH:17]1[CH:12]2[CH2:18][CH:15]([CH2:14][CH:13]2[C:19]([OH:21])=[O:20])[CH2:16]1

Participants

Conditions

Temperature: 65 °C

Procedure

In a 50-mL one neck round bottom flask, 2-naphthalenethiol, Catalog No. 270849 from Aldrich Co. (1.50 g) was dissolved in tetrahydrofuran (3.36 g). In the same flask, 5-norbornene-2-carboxylic acid, Catalog No. 147230 from Aldrich Co. (1.32 g), and 2,2′-azobis(2-methylpropionitrile), Catalog No. 441090 from Aldrich Co. (0.014 g), were added. The flask was heated while stirring in a 65° C. oil bath for 24 hours. The product, 6-(2-naphthylthio)bicyclo[2.2.1]heptane-2-carboxylic acid (2.82 g) was isolated by removing tetrahydrofuran by rotary evaporation.

Workup

addition(0.014 g), were added
temperatureThe flask was heated

Sources & evidence

ORD record: ord-64b9c5b953b54476b90a4db9b3b45afb
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07629424B2

Reaction notes

Loading…