p-Toluenesulfonic acid → HCID 54724194, compound

HRID 1866983Notes

Reaction equation

HRID 1866983 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])O[C:4](=[O:9])[CH:3]=1.[CH3:10][C:11]1[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[C:12]=1[NH2:13].C1(C)C=CC(S(O)(=O)=O)=CC=1>>[CH3:10][C:11]1[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[C:12]=1[N:13]1[C:6]([CH3:8])=[CH:7][C:2]([OH:1])=[CH:3][C:4]1=[O:9]

Participants

4

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 68962,6-DimethylanilineHCID 546757574-Hydroxy-6-methyl-2-pyrone

Product 1

HCID 54724194HCID 54724194, compound

Conditions

Temperature
140 °C

Procedure

A mixture of 4-hydroxy-6-methyl-2-pyrone (2.5 g, 0.02 mol), 2,6 dimethylaniline (2.4 g, 0.02 mol), and p-toluenesulfonic acid (0.2 g) as heated at 140° C. for 3 h under nitrogen atmosphere. The reaction mixture was cooled, triturated with acetonitrile, cooled and filtered the solids.

Workup

  1. temperatureThe reaction mixture was cooled
  2. customtriturated with acetonitrile
  3. temperaturecooled
  4. filtrationfiltered the solids

Sources & evidence

ORD record
ord-3b340be9adf14ecda74ec3834ecf587d
Source dataset
uspto-grants-2009_12
Patent number
US07629363B2

Reaction notes

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