Sodium Chloride → HCID 11217581, compound

HRID 1867198Notes

Reaction equation

HRID 1867198 reaction equation
[CH:1]1(/[CH:7]=[CH:8]/[C:9]([OH:11])=O)[CH2:6][CH2:5][CH:4]=[CH:3][CH2:2]1.ClC(OCC)=O.[CH2:18]([N:20](CC)CC)[CH3:19].C(N)C.[Cl-].[Na+]>C1COCC1>[CH2:18]([NH:20][C:9](=[O:11])/[CH:8]=[CH:7]/[CH:1]1[CH2:6][CH2:5][CH:4]=[CH:3][CH2:2]1)[CH3:19]

Participants

7

Reactant 5

HCID 5234Sodium ChlorideHCID 6341EthylamineHCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 5364373HCID 5364373, compound

Product 1

HCID 11217581HCID 11217581, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-(3-Cyclohexenyl)-2E-propenoic acid 1 eq, ethyl chloroformate 1.5 eq, triethylamine 1.5 eq, ethylamine 1.5 eq as a 2.0M solution in THF, quench with 10% sodium chloride solution, yield=39%.

Sources & evidence

ORD record
ord-704351d834724b549afb9fced85881c0
Source dataset
uspto-grants-2009_12
Patent number
US07632531B2

Reaction notes

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