反应详情

温度

50 °C

A solution of sodium dithionite (772 mg) in water (6 mL) was added to a solution of N-(2,6-diethyl-4-nitro-phenyl)-4-methyl-benzenesulfonamide (309 mg) in tetrahydrofuran (6 mL) and the resulting mixture was stirred at 50° C. for 20 hours. After cooling, the water was saturated with potassium carbonate and extracted with ethyl acetate (2×10 mL). The combined organic phases were dried over sodium sulfate, concentrated in vacuo and purified by flash chromatography to furnish 70 mg (25%) of the title compound as a off-white solid. The product was used directly in the following reaction without spectral characterization.

1. temperatureAfter cooling
2. extractionextracted with ethyl acetate (2×10 mL)
3. dry with materialThe combined organic phases were dried over sodium sulfate
4. concentrationconcentrated in vacuo
5. custompurified by flash chromatography