HCID 19029125, compound → 4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine

HRID 1867373Notes

Reaction equation

HRID 1867373 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([C:17]2[O:18][C:19]([CH3:22])=[N:20][N:21]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CCOC(C)=O.[Pd]>[CH3:22][C:19]1[O:18][C:17]([CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)=[N:21][N:20]=1

Participants

4

Reactant 1

HCID 19029125HCID 19029125, compound

Product 1

HCID 190291464-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidineYield 100.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A suspension of 100 mg (0.33 mmol) of 4-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidine-1-carboxylic acid benzyl ester in 5 ml EtOAc and 10 mg Pd/C 10% was hydrogenated (1 atm) for 1 h. The reaction was filtered (Celite) and evaporated to give 55.4 mg (99%) of the title compound as white solid. MS: 167.9 (MH+).

Workup

  1. customfor 1 h
  2. filtrationThe reaction was filtered (Celite)
  3. customevaporated

Sources & evidence

ORD record
ord-5c51b251093249d28cbae4a9124eacd3
Source dataset
uspto-grants-2009_12
Patent number
US07632829B2

Reaction notes

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