Sodium Iodide → 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-4-(4-iodo-butyl)-[1,4]diazepan-5-one
Reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:12](=[O:13])[CH2:11][CH2:10][N:9]([C:14](=[O:25])/[CH:15]=[CH:16]/[C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([Cl:24])[CH:18]=2)[CH2:8][CH2:7]1.[I-:26].[Na+]>>[Cl:24][C:19]1[CH:18]=[C:17](/[CH:16]=[CH:15]/[C:14]([N:9]2[CH2:10][CH2:11][C:12](=[O:13])[N:6]([CH2:5][CH2:4][CH2:3][CH2:2][I:26])[CH2:7][CH2:8]2)=[O:25])[CH:22]=[CH:21][C:20]=1[Cl:23]Participants
3
Conditions
- Temperature
- 90 °C
Procedure
In analogy to the procedure described in example 6D, 4-(4-chloro-butyl)-1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one and sodium iodide were stirred at 90° C. for 26 h to give the title compound as orange foam. MS: 495.0 (MH+, 2Cl).
Sources & evidence
- ORD record
- ord-fd0250e75bc74e1eb188273e06126747
- Source dataset
- uspto-grants-2009_12
- Patent number
- US07632829B2
Reaction notes
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