Sodium Iodide → 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-(5-iodo-pentyl)-[1,4]diazepan-5-one
Reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[C:13](=[O:14])[CH2:12][CH2:11][N:10]([C:15](=[O:26])/[CH:16]=[CH:17]/[C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=2)[CH2:9][CH2:8]1.[I-:27].[Na+]>>[Cl:25][C:20]1[CH:19]=[C:18](/[CH:17]=[CH:16]/[C:15]([N:10]2[CH2:11][CH2:12][C:13](=[O:14])[N:7]([CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][I:27])[CH2:8][CH2:9]2)=[O:26])[CH:23]=[CH:22][C:21]=1[Cl:24]Participants
3
Conditions
- Temperature
- 90 °C
Procedure
In analogy to the procedure described in example 6D, 4-(5-chloro-pentyl)-1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one and sodium iodide were stirred at 90° C. for 20 h to give the title compound as orange oil. MS: 509.2 (MH+, 2Cl).
Sources & evidence
- ORD record
- ord-a5843e680478422ea7d91c2d47df035c
- Source dataset
- uspto-grants-2009_12
- Patent number
- US07632829B2
Reaction notes
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