Nitrogen → HCID 11564957, compound

HRID 1867569Notes

Reaction equation

HRID 1867569 reaction equation
Br[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([NH2:11])=[N:7][NH:8]2)=[CH:4][CH:3]=1.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17](B(O)O)=[CH:16][CH:15]=1.N#N>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([C:2]2[CH:10]=[C:9]3[C:5]([C:6]([NH2:11])=[N:7][NH:8]3)=[CH:4][CH:3]=2)=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 947NitrogenHCID 201262(4-Methoxyphenyl)boronic acidHCID 27866316-bromo-1H-indazol-3-amine

Product 1

HCID 11564957HCID 11564957, compound

Reagents, catalysts & solvents 1

HCID 9811564Bis(dibenzylideneacetone)palladiumCatalyst

Procedure

A commercial “Miniblock” reactor was charged with trityl-resin bearing 6-bromo-1H-indazol-3-amine (95 mg, 0.066 mmol); 4-methoxyphenylboronic acid (0.3 mmol); Pd2dba3 (5 mg). Subsequently the reactor was sealed and the reaction mixture was put under inert atmosphere (N2 or Ar).

Workup

  1. additionA commercial “Miniblock” reactor was charged with trityl-resin
  2. customSubsequently the reactor was sealed

Sources & evidence

ORD record
ord-de61ca4899384a17be7a5584a6c0fb9d
Source dataset
uspto-grants-2009_12
Patent number
US07632854B2

Reaction notes

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