2-Chloroethyl isocyanate → HCID 68566485, compound

HRID 1867575Notes

Reaction equation

HRID 1867575 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.[Cl:15][CH2:16][CH2:17]N=C=O>O1CCCC1>[C:11]([O:10][C:8]([N:5]1[CH2:4][CH2:3][CH:2]([NH:1][CH2:17][CH2:16][Cl:15])[CH2:7][CH2:6]1)=[O:9])([CH3:14])([CH3:13])[CH3:12]

Participants

4

Reactant 2

HCID 160352-Chloroethyl isocyanateHCID 12682914-Amino-1-Boc-piperidine

Product 1

HCID 68566485HCID 68566485, compoundYield 116.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 4-amino-1-t-butoxycarbonylpiperidine (200 mg, 1.0 mmol) in tetrahydrofuran (5 mL) was treated with 2-chloroethyl isocyanate (0.090 mL, 1.0 mmol) overnight. The solvent was evaporated to provide the title compound as a white solid (305 mg).

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-abf51cf21fe442d4938cbf3b8fb835b8
Source dataset
uspto-grants-2009_12
Patent number
US07632832B2

Reaction notes

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