HCID 68565701, compound → HCID 57979565, compound

HRID 1867591Notes

Reaction equation

HRID 1867591 reaction equation
[CH2:1]([CH:8]1[CH2:12][N:11]([CH:13]2[CH2:18][CH2:17][N:16](CC3C=CC=CC=3)[CH2:15][CH2:14]2)[C:10](=[O:26])[NH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd].C(O)C.Cl>[CH2:1]([CH:8]1[CH2:12][N:11]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[C:10](=[O:26])[NH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 1

HCID 68565701HCID 68565701, compound

Product 1

HCID 57979565HCID 57979565, compoundYield 89.7%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

10% palladium on carbon (10 mg) was added to a solution of 4-benzyl-1-(1-benzylpiperidin-4-yl)imidazolidin-2-one (30 mg, 0.086 mmol) in ethanol (15 mL) and concentrated hydrochloric acid (0.05 mL). The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (40 psi). After 16 h, the mixture was filtered and concentrated to give the title compound (20 mg). MS 260.3 (M+1)

Workup

  1. customThe reaction vessel was evacuated
  2. additionback-filled with nitrogen (3×)
  3. additionback-filled with hydrogen (40 psi)
  4. filtrationthe mixture was filtered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-c8c9761e6bd44d6fb873bf290981dcf8
Source dataset
uspto-grants-2009_12
Patent number
US07632832B2

Reaction notes

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