Hydrochloric Acid → HCID 68562857, compound

HRID 1867610Notes

Reaction equation

HRID 1867610 reaction equation
FC(F)(F)C(O)=O.C(OC([N:15]([CH2:32][CH:33]([NH:40]S(C(C)(C)C)=O)[C:34]1[CH:39]=[CH:38][N:37]=[CH:36][CH:35]=1)[CH:16]1[CH2:21][CH2:20][N:19]([C:22]([O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:23])[CH2:18][CH2:17]1)=O)(C)(C)C.Cl.O1CCOCC1>ClCCl>[NH2:40][CH:33]([C:34]1[CH:39]=[CH:38][N:37]=[CH:36][CH:35]=1)[CH2:32][NH:15][CH:16]1[CH2:21][CH2:20][N:19]([C:22]([O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:23])[CH2:18][CH2:17]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 312751,4-DioxaneHCID 68567233HCID 68567233, compound

Product 1

HCID 68562857HCID 68562857, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (5 mL) was added to a solution of benzyl 4-((tert-butoxycarbonyl){2-[(tert-butylsulfinyl)amino]-2-pyridin-4-ylethyl}amino)piperidine-1-carboxylate (230 mg, 0.412 mmol) in dichloromethane (10 mL). After 1 h, the reaction was concentrated, dissolved in methanol (5 μL), and treated with 4 N HCl in dioxane (4.12 mmol). After 1 h, the reaction was concentrated to give the title compound. MS 355.2 (M+1)

Workup

  1. concentrationthe reaction was concentrated
  2. dissolutiondissolved in methanol (5 μL)
  3. waitAfter 1 h
  4. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-1529d04ce03c438b8dfcf41a2ad870dc
Source dataset
uspto-grants-2009_12
Patent number
US07632832B2

Reaction notes

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