Acetic Anhydride → 3-CHLOROPHENYL ACETATE

HRID 1867655Notes

Reaction equation

HRID 1867655 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C(N(CC)CC)C.[C:16](OC(=O)C)(=[O:18])[CH3:17]>ClCCl>[C:16]([O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)(=[O:18])[CH3:17]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 79333-ChlorophenolHCID 8471Triethylamine

Product 1

HCID 830613-CHLOROPHENYL ACETATE

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-chlorophenol was dissolved in dichloromethane. Triethylamine (1 eq) and acetic anhydride (2 eq) were added. The mixture was stirred at room temperature for 5 hours. Solvent was eliminated by vacuum evaporation. The evaporation residue was taken up in dichloromethane, dried on magnesium sulfate and the solvent was eliminated by vacuum evaporation. Purification was carried out by chromatography on silica gel (elution: cyclohexane/ethyl acetate 95:5).

Workup

  1. customSolvent was eliminated by vacuum evaporation
  2. customdried on magnesium sulfate
  3. customthe solvent was eliminated by vacuum evaporation
  4. customPurification

Sources & evidence

ORD record
ord-03d594e9f1c64e2a94ad858d57b0bbd3
Source dataset
uspto-grants-2009_12
Patent number
US07632870B2

Reaction notes

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