Acetic Anhydride → Phenol, 3-bromo-, 1-acetate

HRID 1867657Notes

Reaction equation

HRID 1867657 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C(N(CC)CC)C.[C:16](OC(=O)C)(=[O:18])[CH3:17]>ClCCl>[C:16]([O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)(=[O:18])[CH3:17]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 115633-Bromophenol

Product 1

HCID 141946Phenol, 3-bromo-, 1-acetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-bromophenol was dissolved in dichloromethane. Triethylamine (1 eq) and acetic anhydride (2 eq) were added and the mixture was stirred at room temperature for 5 hours. The solvent was eliminated by vacuum evaporation.

Workup

  1. customThe solvent was eliminated by vacuum evaporation

Sources & evidence

ORD record
ord-925a0c54b5da44c19aab85d1c2ca7ae4
Source dataset
uspto-grants-2009_12
Patent number
US07632870B2

Reaction notes

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