Hydrochloric Acid → HCID 69031047, compound

HRID 1867934Notes

Reaction equation

HRID 1867934 reaction equation
[CH3:1][O:2][C:3]1[CH:34]=[C:33]([O:35][CH3:36])[CH:32]=[CH:31][C:4]=1[CH2:5][N:6]1[C:15]2[C:10](=[C:11]([CH3:24])[C:12]([F:23])=[C:13]([N:16]3[CH2:20][CH2:19][CH2:18][C@H:17]3[CH2:21][OH:22])[N:14]=2)[C:9](=[O:25])[C:8]([C:26]([O:28]CC)=[O:27])=[CH:7]1.[OH-].[Li+].O.Cl>CO>[CH3:1][O:2][C:3]1[CH:34]=[C:33]([O:35][CH3:36])[CH:32]=[CH:31][C:4]=1[CH2:5][N:6]1[C:15]2[C:10](=[C:11]([CH3:24])[C:12]([F:23])=[C:13]([N:16]3[CH2:20][CH2:19][CH2:18][C@H:17]3[CH2:21][OH:22])[N:14]=2)[C:9](=[O:25])[C:8]([C:26]([OH:28])=[O:27])=[CH:7]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 69030576HCID 69030576, compound

Product 1

HCID 69031047HCID 69031047, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of EXAMPLE 3A (312 mg) and 1M lithium hydroxide (1.9 mL) in methanol (6 mL) at 25° C. was stirred for 24 hours, treated with water (100 mL), adjusted to pH 3 with 1M hydrochloric acid, and filtered.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-fc9a56d2c0ac4f33a556e64f107c8334
Source dataset
uspto-grants-2009_12
Patent number
US07632946B2

Reaction notes

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