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HRID1867961

反应详情

EQUATION

反应方程式

HRID 1867961 的结构方程式

REACTANTS

反应物

2
结构：CN
HCID6329

Methylamine

CH5N

结构：O=C(Nc1nc2ccc(OS(=O)(=O)c3ccc(F)cc3)cc2s1)C1CC1
HCID11523999

未命名化合物

PRODUCTS

生成物

1
结构：CNc1ccc(S(=O)(=O)Oc2ccc3nc(NC(=O)C4CC4)sc3c2)cc1
HCID11603789

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN1CCCC1=O
溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

A solution of 4-fluorobenzenesulfonic 2-(cyclopropanecarbonylamino)benzo-thiazol-6-yl ester (example 7) (25 mg, 63.71 μmol) and methylamine (2N in MeOH, 200 μl) in 300 μl of NMP is heated at 150° C. by microwave for 3 minutes. The crude reaction product is purified by preparative LC/MS (basic medium (pH 9)) to give after freeze-drying 6.7 mg of 4-methylaminobenzene-sulfonic 2-(cyclopropanecarbonylamino)benzothiazol-6-yl ester (beige-colored solid).

WORKUP

后处理

  1. customThe crude reaction product
  2. customis purified by preparative LC/MS (basic medium (pH 9))
  3. customto give
  4. dry with materialafter freeze-drying 6.7 mg of 4-methylaminobenzene-sulfonic 2-(cyclopropanecarbonylamino)benzothiazol-6-yl ester (beige-colored solid)